Publications on the project |
052 Nanomaterials for medical destination |
Authors: | Edited by A.P. Shpak, V.F. Chekhun
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Summary: | Nanomaterials for medical destination
Edited by A.P. Shpak, V.F.Chekhun
Kyiv, Naukova dumka 2011
In Russian:
444 р.
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Keywords: | | |
Edition: | Kyiv, Naukova dumka | | | 2011,
,Russian |
052 Biofunctionalization of Nanomaterials and Nanocomposites |
Authors: | Gorbyk P.P., Gorobets S.V., Turelyk M.P., Chekhun V.F., Shpak A.P. | |
Summary: | The textbook is devoted to implementation of novel scientific research to the educational program of the institutions of higher education. The work touches upon a problem of actual modern ways of biofunctionalized nanocomposites synthesis, investigation and application in the field of medicine, biology and biotechnology. Scientific data and practical research guidance may be used by teachers and students in carrying out educational programs of certain specialties in the institutions of higher education. Theoretical elucidation and practical description of multifunctional magnetosensitive nanocomposites creation with functions of biomedical nanorobots is devoted to new skills obtaining in the field of nanotechnology.
For students, postgraduate students, lecturers and specialists in the field of chemistry, biology and related technological and medical specializations.
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Keywords: | | |
Edition: | Kyiv, Naukova dumka | | | 2011,
,Ukrainian |
052 Biofunctionalized nanomaterials and nanocomposites. Scientific bases and trends of use |
Authors: | Gorbyk P.P., Turelyk M.P., Gorobets S.V., Gorobets O.Yu., Demyanenko I.V. | |
Summary: | Biofunctionalized nanomaterials and nanocomposites. Scientific bases and trends of use
Gorbyk P.P., Turelyk M.P., Gorobets S.V., Gorobets O.Yu., Demyanenko I.V.
Електронне видання НМУ № Е 12/13-090. - Київ: НТТУ (КПІ)
2013. In Ukrainian: 480 р.
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Keywords: | | |
Edition: | | | | 2013,
,Ukrainian |
052 Nanomaterials for medical destination. Ed. V.V. Skorokhod |
Authors: | Uvarova I.V., Gorbyk P.P., Gorobets S.V., Ivashchenko O.A., | |
Summary: | Nanomaterials for medical destination. Ed. V.V. Skorokhod
Kyiv, Naukova dumka
Uvarova I.V., Gorbyk P.P., Gorobets S.V., Ivashchenko O.A., Ulyanchenko N.V.
2014. In Ukrainian: 415 р.
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Keywords: | | |
Edition: | Kyiv, Naukova dumka | | | 2014,
,Ukrainian |
052 Modern problems of surface physics and chemistry: Magnetosensitive nanocomposites with functions of nanorobots and atom-like nanostructures |
Authors: | P. Gorbyk, S. Pokutnyi | |
Summary: | Modern problems of surface physics and chemistry: Magnetosensitive nanocomposites with functions of nanorobots and atom-like nanostructures
Palmarium Academic Publishing
P. Gorbyk, S. Pokutnyi
2013. In Eglish: 212 р.
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Keywords: | | |
Edition: | Palmarium Academic Publishing | | | 2013,
,English |
052 Magnetosensitive Nanocomposites with Functions of Medico-Biological Nanorobots: Synthesis and Properties . Chapter 9. |
Authors: | Gorbyk P.P, Lerman, L.B., Petranovska A.L. and Turanska S.P. | |
Summary: | The results of studies are generalized in order to support the concept of chemical design of magnetically sensitive nanocomposites with multi-level hierarchical architecture and functions of medicobiological nanorobots: recognition of microbiological objects in biological media; the targeted drug delivery into target cells and organs, and deposit; complex treatment with chemo-, immuno-, radio-, hyperthermic methods and real-time diagnostics; adsorption of residual cell debris and removing them from the body with the help of an external magnetic field. The data regarding the synthesis, properties, and practical use of nanocomposites is given. | |
Keywords: | magnetic sensitive nanocomposites, multilevel hierarchical nanoarchitecture, medicobiological nanorobots, targeted drug delivery | |
Edition: | Nova Science Publishers, New York | | | 2014,
161-198,English |
052 Nanocomposites with functions of biomedical nanorobots: synthesis, properties, applications |
Authors: | Gorbyk P.P. | |
Summary: | The results of studies are generalized in order to support both concept and methodology of chemical design of magnetically sensitive nanocomposites with multilevel hierarchical architecture and functions of biomedical nanorobots: recognition of microbiological objects in biological media; the targeted drug delivery into target cells and organs, and deposit; complex treatment with chemo-, immuno-, radio-, hyperthermic methods and diagnostics in real-time
regime; adsorption of residual cell debris and removing them from the body with the aid of an external magnetic field. The data are shown on the synthesis, properties, and practical use of nanocomposites. | |
Keywords: | magnetosensitive nanocomposites, multilevel hierarchical nanoarchitecture, biomedical nanorobots, targeted drug delivery | |
Edition: | Nanosystems, nanomaterials, nanotechnology, vol. 11, № 2 | | | 2013,
323-436,English |
052 Formation of biomimetic hydroxyapatite on titanium surface |
Authors: | Petranovskaya A.L., Turelyk M.P., Pylypchuk Ie.V., Gorbyk P.P., Korduban O.M., Ivasishin O.M. | |
Summary: | Materials based on hydroxyapatite (HA) are widely used in bone grafting and prosthetics. Creating unique materials based on titanium and biomimetically grown HA we can reduce the risk of rejection of implants. Developed a method of modifying the surface of titanium with polymeric modifiers (for creating functional groups on the surface), followed by formation layer of biomimetic hydroxyapatite in medium of model physiological fluid. FTIR and XPS spectroscopy investigations confirmed the formation of hydroxyapatite coatings on titanium surface. | |
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Edition: | Metalofiz. Noveishie Tekhnol. v. 35, №11 | | | 2013,
1567-1584,Russian |
052 Gadolinium- boron-containing nanocomposites based on magnetite |
Authors: | Pylypchuk Ie.V., Petranovskaya A.L., Gorbyk P.P., Korduban A.M., Rohovtsov A.A., Shevchenko Yu.B. | |
Summary: | Developed method of synthesis of magnetically sensitive nanostructures, based on nanocrystalline magnetite containing gadolinium and boron. By atomic emission spectrometry with inductively coupled plasma, X-ray diffraction analysis and X-ray photoelectron spectroscopy studied composition and structure of the obtained compounds. Found, that the synthesis on the surface of nanosized magnetite particles lead to formation an amorphous phase of gadolinium borate. It was shown, that the formation of the crystalline phase GdBO3 occurs after annealing at 950 °C. | |
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Edition: | Metalofiz. Noveishie Tekhnol. V. 36, № 6 | | | 2014,
767-777,Ukrainian |
052 The method for producing of nanocomposite material |
Authors: | Gorbyk P.P., Petranovska A.L., Pylypchuk Ie.V., Gorobets’ S.V., Abramov M.V., Vasilyeva O.A. | |
Summary: | A method for producing of nanocomposite material that includes synthesis of magnetite by mixing solutions of iron salts. Then carry out stabilization by sodium oleate, add ammonia, filtered, dried at room temperature and perform processing magnetite by modifying Gd-containing compound. Aditionally processing stabilizing by surfactant. This modification is carried out at 75-85 ° C at pH 8,5-10, as Gd-containing compound using gadolinium nitrate, and as a stabilizing agent - PEG. | |
Keywords: | nanocomposite material, magnetite, gadolinium-containing compound | |
Edition: | | | | 2014,
,Ukrainian |
052 Magnetosensitive neutron capturing nanocomposite material |
Authors: | Gorbyk P.P., Petranovska A.L., Pylypchuk Ie.V., Abramov M.V., Vasilyeva O.A, Мolodkin V.B, Кulish M.P., Dmytrenko O.P. | |
Summary: | Magnetosensitive neutron capturing nanocomposite material containing carrier, complex - dietylentryamin penta acetic acid with Gd-containing component. Additionally contain modifier 3-aminopropiltryetoxysilane, as the carrier are magnetite complex with dithyletryaminepentaacetic acid with gadolinium sulfate. | |
Keywords: | magnetite, dithyletryaminepentaacetic acid, gadolinium sulfate, 3-aminopropiltryetoxysilane | |
Edition: | Patent of Ukraine | | | 2014,
,Ukrainian |
052 Magnetic fluid |
Authors: | Gorbyk P.P., Petranovska A.L., Abramov M.V., Turelyk M.P., Pylypchuk Ie.V., Vasilyeva O.A. | |
Summary: | Magnetic fluid includes magnetite, stabilizer and solvent. It further comprises modifiers of organic or inorganic origin, and as a stabilizer are sodium oleate. | |
Keywords: | magnetite, sodium oleate | |
Edition: | | | | 2013,
,Ukrainian |
052 Magnetosensitive nanocomposite material |
Authors: | Gorbyk P.P., Petranovska A.L., Pylypchuk Ie.V., Abramov M.V., Vasilyeva O.A. | |
Summary: | Magnetosensitive nanocomposite material containing iron-component - iron and gadolinium borate, which is characterized in that it contains both as iron-component - magnetite, and as gadolinium borate - a mixture of gadolinium ortoborate and gadolinium tetraborate, and additionally as a stabilizer - polyethylene glycol. | |
Keywords: | magnetite, gadolinium borate, polyethylene glycol | |
Edition: | Pat. of Ukraine № 91476 for useful model from 10.07.2014 | | | 2014,
,Ukrainian |
052 Magnetocarried sorbent for purification of biologic liquids from cis-dichlorodiammineplatinum complexes |
Authors: | Gorbyk P.P., Petranovska A.L., Kaminskyi O.M., Kusyak N.V., Turanska S.P., Vasilyeva O.A., Abramov M.V. | |
Summary: | A useful model refers to magnetocarried sorbents for intracorporal (enterosorption) and extracorporal purification of biologic liquids from cis-dichlorodiammineplatinum complexes which can be used in medicine.
Magnetocarried sorbent for purification of biologic liquids from cis-dichlorodiammineplatinum complexes contains magnetite and a shell with silicon oxide, or aluminium oxide, or titanium oxide layer.
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Edition: | Patent of Ukraine on useful model № 87071. 27.01. 2014. | | | 2014,
,Ukrainian |
052 Magnetic antitumour fluid |
Authors: | Paton B.Ye., Gorbyk P.P., Petranovska A.L., Turelyk M.P., Abramov M.V., , Vasilyeva O.A., Chekhun V.F., Lukyanova N.Yu. | |
Summary: | Magnetic antitumour fluid containing magnetite, stabilizer and solvent differs in that it additionally contains modifier and antitumour agent (cisplatin or doxorubicin). | |
Keywords: | magnetite, sodium oleate, polyethylene glycol, cytostatic drug. | |
Edition: | Patent of Ukraine on useful model № 78473. 25.03.2013. | | | 2013,
,Ukrainian |
052 Method for increasing antitumour activity of cisplatin |
Authors: | Chekhun V.F., Lukyanova N.Yu., Todor I.M., Naleskina L.A., Demarsh D.V., Lozovska Yu.V., Gorbyk P.P., Petranovska A.L. | |
Summary: | Increase in therapeutic activity of antitumour drugs is solved by application of platinum-containing drug as “cisplatin-magnetic fluid” nanocomposite in concentration of cisplatin corresponding to free drug doses according to standard chemotherapy schemes. “Cisplatin-magnetic fluid” nanocomposite consists of Fe3O4 nanoparticles stabilized with sodium oleate, with size of 10-12 nm, conjugated by cisplatin. Valuation of cytotoxic and antitumour effects of the nanocomposite was carried out on indices of alive and dead cell ratio in vitro and tumor mass in vivo. | |
Keywords: | magnetite, sodium oleate, polyethylene glycol, drug, antitumour activity | |
Edition: | Patent on useful model № 80767. 10.06.2013 | | | 2013,
,Ukrainian |
052 Temporary technologic regulations onto manufacturing a substance “Magnetite U” ТТР 03291669.012:2012 |
Authors: | Gorbyk P.P., Abramov M.V., Petranovska A.L., Turelyk M.P., Vasilyeva O.A. | |
Summary: | Magnetite U is a nanodispersive powder of black color with specific surface area of 90 – 180 m2g-1, having low toxicity, without negative reactions of human organism on injection, with high level of mutagenic safety, for application in medicine, biology, chemical and other fields. | |
Keywords: | magnetite, biocompatibility, toxicity, bioobjects | |
Edition: | Certificate on author right registration № 46056 | | | 2014,
,Ukrainian |
The events in the framework of the project |
052 052 052 052 052 052 052 052 052
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052 2.2. Chemistry and electrochemistry nanoheterostructures and hybrid nanocomposites Purpose:The main purpose of the research is obtaining of new fundamental knowledge about patterns of physical and chemical processes of chemical synthesis and hierarchical design of nanostructured systems of medical and biological applications, their interaction with external physical fields, radiation, biologically active substances, microbiological objects and development of scientific bases of creation of multifunctional nanocomposites for diagnostics, targeted drug delivery, identification of microbiological objects bind toxins and destroy products of specific cells and removing products of decomposition of the body. Expected results:Release of new product: material Stage 1:Experimental study of the fundamental processes of chemical reactions of adsorbed, chemisorbed, encapsulated and supramolecular structures in supramolecular and nano materials structure organization processes Stage 2:Study and modeling of physical and chemical processes of chemical synthesis and design of inorganic, organic and hybrid nanosystems and supramolecular structures with hierarchical architecture and controlled on an atomic and molecular level design of developed surface Stage 3:Creating new types of advanced nanomaterials and supramolecular structures and investigatiom of their properties. Development of scientific principles of modern nanotechnologies Stage 4:The study of processes of directed synthesis and study of properties of new functionalized nanomaterials, nanocomposites and supramolecular structures Stage 5:Creation of scientific bases of promising nanotechnologies, nanomaterials, nanocomposites and supramolecular structures. Scientific substantiation of directions of their practical use
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