Publications on the project |
097 Nanomaterials for medical destination |
Authors: | Edited by A.P. Shpak, V.F. | |
Summary: | Nanomaterials for medical destination
Edited by A.P. Shpak, V.F.
2011
In Russian:
444 р.
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Keywords: | | |
Edition: | Kyiv, Naukova dumka | | | 2011,
,Russian |
097 Biofunctionalization of Nanomaterials and Nanocomposites |
Authors: | Gorbyk P.P., Gorobets S.V., Turelyk M.P., Chekhun V.F., Shpak A.P. | |
Summary: | The textbook is devoted to implementation of novel scientific research to the educational program of the institutions of higher education. The work touches upon a problem of actual modern ways of biofunctionalized nanocomposites synthesis, investigation and application in the field of medicine, biology and biotechnology. Scientific data and practical research guidance may be used by teachers and students in carrying out educational programs of certain specialties in the institutions of higher education. Theoretical elucidation and practical description of multifunctional magnetosensitive nanocomposites creation with functions of biomedical nanorobots is devoted to new skills obtaining in the field of nanotechnology.
For students, postgraduate students, lecturers and specialists in the field of chemistry, biology and related technological and medical specializations.
2011. In Ukrainian: 283 р.
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Keywords: | | |
Edition: | Kyiv, Naukova dumka | | | 2011,
,Ukrainian |
097 Biofunctionalized nanomaterials and nanocomposites. Scientific bases and trends of use |
Authors: | Gorbyk P.P., Turelyk M.P., Gorobets S.V., Gorobets O.Yu., Demyanenko I.V. | |
Summary: |
Gorbyk P.P., Turelyk M.P., Gorobets S.V., Gorobets O.Yu., Demyanenko I.V.
Електронне видання НМУ № Е 12/13-090. - Київ: НТТУ (КПІ)
2013. In Ukrainian: 480 р.
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Keywords: | | |
Edition: | | | | 2013,
480 c.,Ukrainian |
097 Nanomaterials for medical destination. Ed. V.V. Skorokhod |
Authors: | Uvarova I.V., Gorbyk P.P., Gorobets S.V., Ivashchenko O.A., Ulyanchenko N.V. | |
Summary: | Nanomaterials for medical destination. Ed. V.V. Skorokhod
Kyiv, Naukova dumka
Uvarova I.V., Gorbyk P.P., Gorobets S.V., Ivashchenko O.A., Ulyanchenko N.V.
2014. In Ukrainian: 415 р.
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Keywords: | | |
Edition: | Kyiv, Naukova dumka | | | 2014,
,Ukrainian |
097 Modern problems of surface physics and chemistry: Magnetosensitive nanocomposites with functions of nanorobots and atom-like nanostructures |
Authors: | P. Gorbyk, S. Pokutnyi | |
Summary: | Modern problems of surface physics and chemistry: Magnetosensitive nanocomposites with functions of nanorobots and atom-like nanostructures
Palmarium Academic Publishing
P. Gorbyk, S. Pokutnyi
2013. In Eglish: 212 р.
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Keywords: | | |
Edition: | Palmarium Academic Publishing | | | 2013,
,English |
097 6. Magnetosensitive Nanocomposites with Functions of Medico-Biological Nanorobots: Synthesis and Properties . Chapter 9. |
Authors: | Gorbyk P.P, Lerman, L.B., Petranovska A.L. and Turanska S.P. | |
Summary: | The results of studies are generalized in order to support the concept of chemical design of magnetically sensitive nanocomposites with multi-level hierarchical architecture and functions of medicobiological nanorobots: recognition of microbiological objects in biological media; the targeted drug delivery into target cells and organs, and deposit; complex treatment with chemo-, immuno-, radio-, hyperthermic methods and real-time diagnostics; adsorption of residual cell debris and removing them from the body with the help of an external magnetic field. The data regarding the synthesis, properties, and practical use of nanocomposites is given.
Gorbyk P.P, Lerman, L.B., Petranovska A.L. and Turanska S.P.
Advances in Semiconductor Research: Physics of Nanosystems, Spintronics and Technological Applications. Adorno, D.P., Pokutnyi S. (eds.). Nova Science Publishers, New York
Keywords: magnetic sensitive nanocomposites, multilevel hierarchical nanoarchitecture, medicobiological nanorobots, targeted drug delivery
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Keywords: | magnetic sensitive nanocomposites, multilevel hierarchical nanoarchitecture, medicobiological nanorobots, targeted drug delivery | |
Edition: | Nova Science Publishers, New York | | | 2014,
Р. 161-198,English |
097 Nanocomposites with functions of biomedical nanorobots: synthesis, properties, applications |
Authors: | Gorbyk P.P. | |
Summary: | The results of studies are generalized in order to support both concept and methodology of chemical design of magnetically sensitive nanocomposites with multilevel hierarchical architecture and functions of biomedical nanorobots: recognition of microbiological objects in biological media; the targeted drug delivery into target cells and organs, and deposit; complex treatment with chemo-, immuno-, radio-, hyperthermic methods and diagnostics in real-time
regime; adsorption of residual cell debris and removing them from the body with the aid of an external magnetic field. The data are shown on the synthesis, properties, and practical use of nanocomposites.
2013. In Eglish: Р. 323-436
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Keywords: | magnetosensitive nanocomposites, multilevel hierarchical nanoarchitecture, biomedical nanorobots, targeted drug delivery | |
Edition: | Nanosystems, nanomaterials, nanotechnology, vol. 11, № 2 | | | 2013,
С. 323-436,English |
097 Formation of biomimetic hydroxyapatite on titanium surface |
Authors: | Petranovskaya A.L. Turelik M.P., Pylypchuk E.V., Gorbyk P.P., Korduban A.M., Ivasishin O.M. | |
Summary: | Materials based on hydroxyapatite (HA) are widely used in bone grafting and prosthetics. Creating unique materials based on titanium and biomimetically grown HA we can reduce the risk of rejection of implants. Developed a method of modifying the surface of titanium with polymeric modifiers (for creating functional groups on the surface), followed by formation layer of biomimetic hydroxyapatite in medium of model physiological fluid. FTIR and XPS spectroscopy investigations confirmed the formation of hydroxyapatite coatings on titanium surface. | |
Keywords: | | |
Edition: | Mettalofiz. Noveish. Techn. v. 35, I11 | | | 2013,
С. 1567‒1584,Russian |
097 Gadolinium- boron-containing nanocomposites based on magnetite |
Authors: | Pylypchuk Ie.V., Petranovskaya A.L., Gorbyk P.P., Korduban A.M.,
Rohovtsov A.A., Shevchenko Yu.B.
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Summary: | nanocrystalline magnetite containing gadolinium and boron. By atomic emission spectrometry with inductively coupled plasma, X-ray diffraction analysis and X-ray photoelectron spectroscopy studied composition and structure of the obtained compounds. Found, that the synthesis on the surface of nanosized magnetite particles lead to formation an amorphous phase of gadolinium borate. It was shown, that the formation of the crystalline phase GdBO3 occurs after annealing at 950 °C.
Metalofiz. Noveishie Tekhnol. V. 36, № 6
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Keywords: | | |
Edition: | Metalofiz. Noveishie Tekhnol. V. 36, № 6 | | | 2014,
767-777,Ukrainian |
097 10. Chemical design of outer surface of mesoporous silicas for controlled storage and release of aromatic amino acid |
Authors: | Roik N.V., Belyakova L.A. | |
Summary: | Mesoporous silicas with hexagonally arranged pore channels were synthesized in water ethanol ammonia solution using cetyltrimethylammonium bromide as template. Directed modification of silica surface with N-[N’-(N’-phenyl)-2-aminophenyl] 3 aminopropyl groups was realized by postsynthetic activation of halogenoalkylsilicas, which have surface uniformly or selectively distributed 3 chloropropyl groups, with 2 aminodiphenylamine in liquid phase. Chemical composition of silica materials was estimated by IR spectroscopy and chemical analysis of surface products of reactions. Characteristics of porous structure of MCM 41 type silicas were determined from X ray and low temperature nitrogen ad desorption measurements. Release ability of synthesized silica carriers were established on encapsulation of 4 aminobenzoic acid in pore channels and subsequent delivery at pH = 6.86 and pH = 1.00. It was found that N-[N’-(N’-phenyl)-2-aminophenyl] 3 aminopropyl groups block pore entrances at neutral pH preventing 4 aminobenzoic acid release. At pH = 1.00 repulsion of positively charged surface aromatic amino groups localized near by pore orifices provides unhindered liberation of aromatic amino acid from mesoporous channels.
J. Solid State Chemistry. – 2014. – V.215
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Keywords: | mesoporous silica; 4 aminobenzoic acid; 2-aminodiphenylamine; selective modification; pH controlled release | |
Edition: | J. Solid State Chemistry. – 2014. – V.215 | | | 2014,
284–291,English |
097 Nanoporous β-cyclodextrin-containing silicas: synthesis, structure and properties |
Authors: | Belyakova L.A., Lyashenko D.Yu., Dzyubenko L.S., Shvets O.M. | |
Summary: | Nanoporous β cyclodextrin containing silicas which differ in functional substituents of wide edge of attached cyclic oligosaccharide molecules (alcohol, bromoacetyl, thiosemicarbazidoacetyl groups) were synthesized. Chemical composition of surface layer of organosilicas and their sorption parameters were determined using IR spectroscopy, isotherms of nitrogen ad-desorption, elemental, chemical and thermogravimetric analyses. Ranges of thermal and chemical stability of synthesized β cyclodextrin containing silicas were defined; a method of organosilicas regeneration was proposed. Activation energies of water removal from the inner cavities of β cyclodextrins and from the surface of functional organosilicas were calculated. Distribution and selectivity coefficients for sorption of mercury (II), coper (II), lead (II), cadmium (II), and zinc (II) cations were computed.
Chemistry, Physics and Technology of Surface. V.5, N4
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Keywords: | silica, β cyclodextrin, chemical immobilization, sorption, heavy metal nitrates, IR spectroscopy, thermogravimetry, regeneration | |
Edition: | Chemistry, Physics and Technology of Surface | | | 2014,
386–395,English |
097 Decoration of MCM-41 pore entrances with amino-containing groups for pH-controlled delivery of para-aminobenzoic acid |
Authors: | Roik N.V., Belyakova L.A., Dziazko M.O., Oranska E.I. | |
Summary: | Selectively modified silica materials with uniform hexagonally ordered cylindrical mesopores were synthesized by combination of sol gel condensation and postsynthetic chemical modification. Hexagonally arranged porous structure of silica carriers was confirmed by X-ray diffraction and low temperature ad desorption of nitrogen. Content of functional groups immobilized onto external surface of silica particles was determined from chemical analysis of surface products of reactions. Release ability of MCM 41 mesoporous silicas selectively modified with N (2 aminoethyl) 3 aminopropyl or N [N’-(N’-phenyl)-2-aminophenyl] 3 aminopropyl groups was studied by use of para aminobenzoic acid as model biologically active substance. It was found that desorption of aromatic amino acid from mesoporous channels of silica can be regulated using pH-sensitive functional groups which are chemically bounded with outer silica surface.
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Keywords: | sol-gel growth; vapour deposition; desorption; surface properties | |
Edition: | Chemistry, Physics and Technology of Surface. V.5, N4 | | | 2014,
404–414,English |
097 13. Effect of β-cyclodextrin attendance on hexagonal ordering of MCM-41 silicas |
Authors: | Trofymchuk I.M., Roik N.V., Belyakova L.A. | |
Summary: | Hydrothermal sol-gel synthesis of hexagonally ordered silicas using a hybrid template system is reported. Hybrid template system was made from ionic surfactant (cetyltrimethylammonium bromide or decyltrimethylammonium bromide) and supramolecular porogen β-cyclodextrin. Tetraethylorthosilicate or its blend with (3-chloropropyl)triethoxysilane were used as matrix precursors. Synthesized silicas were characterized by IR spectroscopy, X-ray diffraction techniques as well as transmission electron microscopy. It was shown that the hexagonal structure of MCM-41 is not changed despite the addition of β cyclodextrin.
Trofymchuk I.M., Roik N.V., Belyakova L.A.
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Keywords: | ordered silica materials; MCM-41; β-cyclodextrin; hydrothermal sol gel synthesis; template | |
Edition: | Proceedings of the International Conference Nanomaterials: Applications and Properties. V.3, N1. | | | 2014,
,English |
097 14. DSC-study of polyhydroxyethylmethacrylate filled with modified silicas |
Authors: | Bolbukh Y. , Tertykh V. , Klonos P. , Pissis P | |
Summary: | Effects of the nature of functional groups (namely, hydroxyl, methyl, silicon hydride, amino, and vinyl) on the surface of pristine and modified silicas on polymerization of 2-hydroxyethylmethacrylate (HEMA) and on structural characteristics of the filled composites have been studied. DSC, FTIR spectroscopy and equilibrium water sorption (ESI) techniques were applied for the composites characterization. Results obtained testify that the chemical nature of the grafted groups has a strong influence on the monomer orientation in the surface layer of the filler. More uniform and cross-linked structures were detected in the composites with particularly methylated silica. Filler with chemically active silicon hydride groups promotes formation of ordered structure with rigid macromolecules. The presence of amino and vinyl groups on the silica surface results in formation of flexible polymer chains with a low cross-linking density or with a low polymerization degree, even at 2 wt% filling degree. Water uptake for composites with vinyl- and amine-containing silicas was low, indicating the close-packing of polymeric molecules in the filled polyHEMA.
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Keywords: | 2-Hydroxyethylmethacrylate (HEMA), Silica fillers, Surface groups, DSC, Composite structure | |
Edition: | J. Therm. Anal. Calorim. V.108, N3 | | | 2012,
1111-1119,English |
097 Chitosan immobilized on the silica surface for the wastewater treatment |
Authors: | Budnyak T., Tertykh V., Yanovska E. | |
Summary: | Adsorbents of natural origin are widely used for industrial wastewater treatment in order to replace current costly methods of heavy metals removing from solutions. For that purpose, immobilization of chitosan on the silica gel surface by crosslinking of adsorbed biopolymer with glutaraldehyde was carried out. Anchorage of chitosan on the silica surface was confirmed by IR spectroscopy. Concentration of immobilized chitosan was estimated using thermogravimetric analysis. The adsorption of microquantities of Zn(II), Cu(II), Cd(II), Pb(II), Fe(III), V(V) and Mo(VI) ions from aqueous solutions by obtained composite has been studied. The highest sorption capacities were observed with respect to zinc (0.46 mmol/g), molybdenum- and vanadium-containing ions (0.31 mmol/g). Diffuse reflectance electronic spectra of samples with different content of adsorbed metal and kinetic adsorption characteristics of the composite adsorbent were estimated. | |
Keywords: | adsorption, chitosan, silica, toxic metals removal, wastewater treatment | |
Edition: | Materials Science (Medžiagotyra). V.20, N2 | | | 2014,
177-182,English |
097 Electron paramagnetic resonance study of paramagnetic centers in carbon-fumed silica adsorbent |
Authors: | Savchenko D.V., Shanina B.D., Kalabukhova E.N., Sitnikov A.A., Lysenko V.S., Tertykh V.A. | |
Summary: | Fumed silica A-300 was carbonized by means of pyrolysis of CH2Cl2. The obtained initial SiO2:C nanopowders of black color, with an average diameter of 14–16 nm and carbon (C) concentration 7 wt. %, subjected to the oxidation and passivation treatment were studied byelectron paramagnetic resonance (EPR) in the temperature range 4–400 K. Two EPR signals of Lorentzian lineshape with nearly equal g-factors and different linewidth were observed in the initial, oxidized, and passivated SiO2:C nanopowders. The two-component EPR spectrum was explained by the presence of C in two electronic states. The intensive narrow EPR signal, which has a temperature-dependent intensity, linewidth, and resonance field position, was attributed to the carbon-related defect with non-localized electron hopping between neighboring C-dangling bonds. The striking effect is that the temperature dependence of the EPR line-width demonstrates the motional narrowing of the EPR signal at very low temperatures from 4 K to 20 K, which is not typically for nonmetallic materials and was explained by the quantum character of C layer conductivity in the SiO2:C. The observed peaks in the temperature dependence of the conduction electron EPR signal integral intensity in the high-temperature range 200–440 K was explained by the presence of the C nanodots at the surface of SiO2 nanoparticles and the ejection of electrons from the confinement energy levels of C quantum dot when the temperature becomes comparable to the confinement energy. | |
Keywords: | Electron paramagnetic resonance spectroscopy, SiO2:C composites, C-dots | |
Edition: | Journal of Applied Physics. V.115, 133704 | | | 2014,
1–7,English |
097 Immobilization of urease on mesoporous materials such as SBA-15 with a functional surface layer |
Authors: | Pogorilyi R.P., Zub Yu.L., Beganskiene A., Kareiva A. | |
Summary: | The template method was used to synthesize mesoporous polysiloxane material of SBA-15 type, which was subsequently modified in ethanol solution with primary and secondary amino groups, and thiol groups. Then, urease was immobilized by adsorption on the surface of the obtained carriers. It was determined that the nature of the functional groups on the surfaces of the carriers affects the kinetics of adsorption, the degree of binding, and residual enzyme activity. | |
Keywords: | SBA-15, functional surface layer, urease, adsorption, activity | |
Edition: | Сhemija. V. 25. N. 2 | | | 2014,
75–81,English |
097 Immobilization of urease on magnetic nanoparticles coated by polysiloxane layers bearing thiol- or thiol and alkyl-functions |
Authors: | Pogorilyi R.P., Melnyk I.V., Zub Y.L., Seisenbaeva G.A. and Kessler V.G. | |
Summary: | Magnetically retrievable formulations of urease potentially promising for biomedical and environmental applications were constructed by immobilization of the enzyme on the surface of magnetite nanoparticles functionalized by siloxane layers with active thiol or thiol-and-alkyl moieties. The latter were deposited using a hydrolytic polycondensation reaction of tetraethoxysilane with either 3-mercaptopropyltrimethoxysilane, or with 3-mercaptopropyltrimethoxysilane and methyltriethoxysilane, or alternatively n-propyltriethoxysilane. Immobilization of urease was carried out in different ways for comparison: by adsorption, by entrapment during the hydrolytic polycondensation reaction, or by covalent bonding. For entrapment the enzyme was introduced into solution before functionalization of the magnetite. Entrapment bound high amounts of enzyme (more than 700 mg per g of carrier), but its activity was decreased compared to the native form to between 18 and 10%. In the case of covalent binding of urease using Ellman's Reagent, binding of the enzyme was almost as efficient as in the case of entrapment but its residual activity was 75%. The residual activity of urease immobilized by adsorption on the surface of thiol-functionalized particles was truly high as compared to that of the native enzyme (97%), but binding was significantly less efficient (46%). Introduction of alkyl functions permitted increase of the amounts of the adsorbed enzyme but its activity was somewhat decreased. | |
Keywords: | Nanoparticles of magnetite, Hydrolytic polycondensation reaction, Trifunctional silanes, HS- or HS/alkyl-containing surface layer, Urease, Immobilization, Activity | |
Edition: | J. Mater. Chem. B 2 | | | 2014,
2694–2702,English |
097 Nuclear magnetic resonance study of interfacial phenomena |
Authors: | Gun’ko V.M., Turov V.V. | |
Summary: | Properties and applications of high surface area materials depend on interfacial phenomena, including diffusion, sorption, dissolution, solvation, surface reactions, catalysis, and phase transitions. Among the physicochemical methods that give useful information regarding these complex phenomena, nuclear magnetic resonance (NMR) spectroscopy is the most universal, yielding detailed structural data regarding molecules, solids, and interfaces. Nuclear Magnetic Resonance Studies of Interfacial Phenomena summarizes NMR research results collected over the past three decades for a wide range of materials—from nanomaterials and nanocomposites to biomaterials, cells, tissues, and seeds.
This book describes the applications of important new NMR spectroscopic methods to a variety of useful materials and compares them with results from other techniques such as adsorption, differential scanning calorimetry, thermally stimulated depolarization current, dielectric relaxation spectroscopy, infrared spectroscopy, optical microscopy, and small-angle and wide-angle x-ray scattering. The text explores the application of NMR spectroscopy to examine interfacial phenomena in objects of increasing complexity, beginning with unmodified and modified silica materials. It then describes properties of various mixed oxides with comparisons to individual oxides and also describes carbon materials such as graphite and carbon nanotubes.
Chapters deal with carbon–mineral hybrids and their mosaic surface structures, and interfacial phenomena at the surface of natural and synthetics polymers. They also explore a variety of biosystems, which are much more complex, including biomacromolecules (proteins, DNA, and lipids), cells and tissues, and seeds and herbs. The authors cover trends in interfacial phenomena investigations, and the final chapter describes NMR and other methods used in the book. This text presents a comprehensive description of a large array of hard and soft materials, allowing the analysis of the structure–property relationships and generalities on the interfacial behavior of materials and adsorbates.
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Keywords: | Nanosilica; Low-temperature 1H NMR; Nitrogen adsorption; Pore size distribution; Interfacial phenomena | |
Edition: | Taylor & Francis. New York | | | 2013,
1070,English |
097 Interfacial behavior of silicone oils interacting with nanosilica and silica gels |
Authors: | Gun’ko V.M., Turov V.V., Krupska T.V., Ruban A.N., Kazanets A.I., Leboda R., Skubiszewska-Zieba J. | |
Summary: | The interfacial behavior of silicone oils Oxane 1000 and Oxane 5700 (polydimethylsiloxanes, PDMS) interacting with dried or hydrated (hydration h = 0.005 or 0.1 g/g) silica gels Si-60 and Si-100 or nanosilica A-400 was studied using low-temperature 1H NMR spectroscopy over the 210–310 K range. Broadening of the melting temperature range toward both sides from the freezing point is observed for silicone oils confined in mesopores (2–15 nm in radius) of silica gel particles (0.2–0.5 mm in size) or voids (1–100 nm) between silica nanoparticles (5–10 nm in size) in their aggregates. This effect is a consequence of the phase state heterogeneity, since both liquid and solid-like fractions of adsorbed PDMS are observed over a large temperature range. The adsorbed PDMS heterogeneity depends on the pore size distribution (confined space effect), and it is lower for silica gel Si-100 possessing broader pores than Si-60. An increase in the amounts of adsorbed polymer and water diminishes the effects of confined space on PDMS because a fraction of the polymers is located in broader pores or out of pores (voids). This leads to relative decrease in interactions of PDMS with the silica surface. 1H NMR spectra of PDMS and n-decane bound to silica gels reveal much stronger heterogenization of adsorbed PDMS (depending on the polymer length) than that of the alkane | |
Keywords: | Silicone oils; Silica gels; Nanosilica; Low-temperature 1H NMR; Nitrogen adsorption; Pore size distribution; Interfacial phenomena | |
Edition: | J. Colloid and Interface Science | | | 2013,
467 – 474.,English |
097 Connection between Alzheimer's disease and structural characteristics of bone tissues studied by 1H NMR method |
Authors: | Jabłoński M., Gun'ko V.M., Golovan A.P., Leboda R., Skubiszhewska-Zieba J., Turov V.V. | |
Summary: | Water, as a probe liquid bound in model systems (highly disperse hydroxyapatite - protein composites as a model of the main components of bones) and rat bone tissues healthy and affected by osteoporosis occurred due to experimental Alzheimer's disease (EAD), has been investigated using low-temperature (1)H NMR spectroscopy, NMR cryoporometry, TG/DTG/DTA, DSC, and TG and DSC thermoporometry. The textural characteristics of these intact systems cannot be studied using the standard adsorption methods, but the cryoporometry and thermoporometry methods give these characteristics. The (1)H NMR spectra of water bound in model and natural bone tissues include signals, which can be assigned to strongly associated (typical) water (SAW, chemical shift of proton resonance δ(H)=5-6 ppm) and weakly associated (atypical) water (WAW) at δ(H)=1-2 ppm. Contributions of SAW and WAW give information on textural organization of both model and natural bones. The influence of such co-adsorbates as HCl, CDCl(3), CD(3)CN, C(6)D(6), and (CD(3))(2)SO on the interfacial behavior and clustering of bound water depends on their polarity, amounts of components, and textural and structural features of the materials analyzed with the (1)H NMR spectroscopy and cryoporometry methods. According to the NMR cryoporometry data, the EAD causes an increase in nanoporosity of the bone tissues. The total porosity and the specific surface area of biostructures (accessible for water molecules and estimated using NMR cryoporometry and TG thermoporometry methods with a model of cylindrical pores) are larger for the EAD sample. Weakly polar chloroform-d has a significant influence on the organization of water in the bone tissue, and this effect is greater for the EAD sample as more porous material. | |
Keywords: | bone tissues, Low-temperature 1H NMR, of strongly and weakly associated water | |
Edition: | J. Colloid and Interface Science | | | 2013,
446 – 462,English |
097 Low-temperature 1H NMR spectroscopic study of hydration properties of a hybrid system based on nanosilica, DNA and doxorubicin in the presence of C60 fullerene |
Authors: | Turov V.V., Prylutskyy Yu.I., Ugnivenko A.P., Barvinchenko V.M., Krupskaya T.V., Tsierkezos N.G., Ritter U. | |
Summary: | The structure of hydrate cover layers of SiO2-DNA-Dox (where Dox: doxorubicin) and SiO2-DNA-Dox-C60 fullerene hybrids was studied by means of low-temperature 1H NMR spectroscopy in tetrachloromethane. The hydration properties of SiO2-DNA-Dox nanomaterials combined with fullerenes and their derivatives are extremely important for their further use as therapeutics in cancer treatment and for safety reasons. The findings reveal that the hydration properties of the hybrids differ from those of the solid DNA particulates or SiO2-DNA systems due to the existence of different types of water clusters, namely the weakly (WAW) and strongly associated water (SAW) clusters. For SAW clusters the radial distributions as well as the distributions of change in Gibbs free energy due to adsorptive interactions at the surfaces of the investigated systems were obtained. | |
Keywords: | Pore size distribution; Interfacial phenomena, of strongly and weakly associated water | |
Edition: | Low Temperature Physics. V.40, N3. | | | 2014,
309 – 316.,English |
097 Effect of trifluoroacetic acid in water clustering partially dehydrated rat liver Guerin carcinoma |
Authors: | Turov V.V., Todor I.M., Lukyanova N.Yu., Krupskaya T.V., Ugnivenko A.P., Chehun V.F | |
Summary: | The state of water in lyophilized liver tissue of rats - intact and impressions by the carcinoma Guerin by the method of low-temperature 1H NMR spectroscopy was investigate. It was founded that in the intact tissue six types of water clusters that can dissolve different amounts of trifluoroacetic acid are presents. In the liver tumor clusters SAW is more homogeneous, and their salvation abilities respect to TFA and electron-donor molecules is significantly smaller. | |
Keywords: | Guerin's carcinoma, water clusters, of strongly and weakly associated water | |
Edition: | Допов. НАН України. №2 | | | 2014,
129 – 135,Ukrainian |
097 The emulsification of humen serum albumin and hyaluronic acid solutions in polydimehylsiloxane PDMS-1000 |
Authors: | Ruban A.N., Kazanets A.I., Krupska T.V., Turov V.V | |
Summary: | To create a biologically inert material suitable for use in a wide range of temperatures and in corrosive environments, the methods of optical microscopy and NMR-cryometry were used for investigation of emulsification of solutions of human serum albumin and hyaluronic acid in polymethylsiloxane PDMS1000. Unlike hyaluronic acid, human serum albumin forms persistent emulsions in the silicon matrix, whose size of the droplets varies from 100 to 10 000 nm. The presence of dispersed phase (human serum albumin or hyaluronic acid) increases significantly melting temperature of polydimethylsiloxane. It is probably due to ordering influence of micro- and nanodrops of biopolymers on PDMS crystals localized between them. In case of dispersion of hyaluronic acid solution in liquid silicone only microdroplets of the aqueous phase are observed and nanosized droplets either didn’t form or were in amount not sufficient to be detected by NMR cryometry. The possibility of a significant influence of human serum albumin emulsified solution on PDMS-1000 defrosting temperature is revealed, that is impacted on its optical parameters. This effect is recorded both in the low temperature region and at temperature close to human body, which might influence on silicone state when it is used as implant. | |
Keywords: | 1Н NMR-spectroscopy, silicone, human serum albumin, hyaluronic acid, water clusters | |
Edition: | Biotechnologia Acta. Т 7. № 2. | | | 2014,
70 – 78,Russian |
097 Hydrate properties of composite material with nanodispersed silica and hyaluronic acid |
Authors: | Ugnivenko A.P., Gun'ko V.M., Krupskaya T.V., Barvinchenko V.M., Turov V.V. | |
Summary: | Differently hydrated composites with A-300 and hyaluronic acid were studied using low-temperature 1H NMR spectroscopy. It was found that all the water adsorbed to composite in air is in strong associated state. Chloroform media has a little effect on the spectral and thermodynamic characteristics of adsorbed water, while a large part of water bound to composite in acetonitrile is in weakly associated state and the chemical shift is reduced to 3 ppm. Signals of SAW and WAW are observed separately in mixed solvents CD3CN-CDCl3. Aqueous solution of hydrochloric acid or hydrogen peroxide interacting with silica can be decomposed into the system of clusters containing different amounts of HCl or H2O2. It was shown that clusters of strongly associated water weakly dissolve acetonitrile or acids. | |
Keywords: | nanosilica, hyaluronic acid, of strongly and weakly associated water, water clusters, chloroform, acetonitrile | |
Edition: | Chemistry, Physics and Technology of Surface. V.3. N 3. | | | 2012,
253 – 264,Russian |
097 Electrophysical properties of polymer composites on the basis of multiwall carbon nanotubes synthesized on a basalt scales |
Authors: | Mazurenko R.V., Zhuravsky S.V., Gunya G.M., Prihod’ko G.P., Makhno S.N., Gorbik P.P., Kartel M.T | |
Summary: | The electrophysical properties of polymer composites (PC) based on polychlorotrifluoroethylene (PCTFE) filled multiwall carbon nanotubes (MCNT) synthesized on the surface of basalt scales have been studied in the superfrequency range and low-frequency. Concentration of MCNT relative to basaltic catalyst is 0.32 volume fractions. It has been shown that the values of real and imaginary рarts of the complex permittivity in the superfrequency range and electrical conductivity at low frequencies depend nonlinearly on the volume content of MCNT in composites. The percolation threshold of system 0.32MCNT/BS–PCTFE has been defined and value is 0.013 volume fractions. | |
Keywords: | multiwall carbon nanotubes, polymer composites, conductivity, dielectric permittivity | |
Edition: | Chemistry, Physics and Technology of Surface. V.5, N 2. | | | 2014,
220 – 225,Ukrainian |
097 The Influence of Nano-Sized Bactericidal Addition on Properties of Polypropylene Fibers |
Authors: | Dzubenko L.S, Tsebrenko ., M.V., Sapyanenko O.O., Gorbyk P.P., Mel’nyk I.A. | |
Summary: | There were polypropylene strings containing combined nano-dimensional addition prepared. The one’s influence on phase transitions and physico-chemical properties in polypropylene (PP) was studied. It is shown, that presence of nano-dimensional addition is broadening the temperature range of PP melting, so indicating crystallites’ formation of more broad dimensional dispersion. There are improving of physico-mechanical properties at her content of 0.1 – 1 % mass. having place: increase of tensile strength and modulus of elasticity, decrease of shrinkage factor at drying conditions. It is established, that polypropylene strings containing Ag/SiO2 addition, having bactericidal properties, what is important for use as seam materials in surgery practice | |
Keywords: | polypropylene fibers, addition of Ag/SiO2, bactericidal properties | |
Edition: | Surface, Science Proceedings Issue , Kyiv, “Naukova Dumka” - Vol.3, 18. - Р. 282–288. – 2011, In Ukrainian. | | | 2011,
282–288,Ukrainian |
097 Method for manufacturing of composite drug granules based on chitosan with controlled release of active substances |
Authors: | Kozakevych R.B., Bolbukh Y.M., Tertykh V.A., Yanyshpolskyi V.V. | |
Summary: | According to the invention, the formation of the granules is carried out by introducing the liquid composite mixture through the capillary in the hydrophobic silica, methylated in particular, that allows keep polymer in water-soluble form. Introducing poorly soluble active substance is carried out at the stage of homogenising of the silica suspension in a solution of chitosan, or the active compound, such as diclofenac sodium, can be initially impregnated onto the silica matrix. As silica matrix can be used hydrophilic or/and hydrophobic silicas with surface groups capable to interact with the active substance. | |
Keywords: | water-soluble chitosan, a functionalized silica, poorly soluble medicament | |
Edition: | Patent of Ukraine No92571, Bull. №21, registered 10.11.2010 | | | 2010,
,Ukrainian |
097 Method of forming on the silica surface the grafted modifying layer with high carbon content |
Authors: | Bolbukh Yu.M., Kozakevych R.B., Tertykh V.A. | |
Summary: | Patent relates to the synthesis of environmentally friendly materials based on silica and polydimethylsiloxane. The demand for such materials is increasing as they are relevant for medical use as adsorbents or carriers of drugs, as thickeners ointments, oils or gels, in technology of bio-adhesive production, in synthesis of composite materials based on organic or silicone polymers. The proposed technology of forming the polysiloxane grafted layer on the inorganic particles surface provides carbon content 6 wt% while maintaining the dispersity of silica. | |
Keywords: | nanodispersed silica, a polydimethylsiloxane, grafted surface layer, a high carbon content | |
Edition: | Patent of Ukraine No 92772, recorded 09.10.2014 | | | 2014,
,Ukrainian |
097 The method for producing of nanocomposite material |
Authors: | Gorbyk P.P., Petranovska A.L., Pylypchuk Ie.V., Gorobets’ S.V., Abramov M.V., Vasilyeva O.A. | |
Summary: | A method for producing of nanocomposite material that includes synthesis of magnetite by mixing solutions of iron salts. Then carry out stabilization by sodium oleate, add ammonia, filtered, dried at room temperature and perform processing magnetite by modifying Gd-containing compound. Aditionally processing stabilizing by surfactant. This modification is carried out at 75-85 ° C at pH 8,5-10, as Gd-containing compound using gadolinium nitrate, and as a stabilizing agent - PEG. | |
Keywords: | nanocomposite material, magnetite, gadolinium-containing compound | |
Edition: | | | | 2014,
,Ukrainian |
097 Magnetosensitive neutron capturing nanocomposite material |
Authors: | Gorbyk P.P., Petranovska A.L., Pylypchuk Ie.V., Abramov M.V., Vasilyeva O.A, Мolodkin V.B, Кulish M.P., Dmytrenko O.P. | |
Summary: | Magnetosensitive neutron capturing nanocomposite material containing carrier, complex - dietylentryamin penta acetic acid with Gd-containing component. Additionally contain modifier 3-aminopropiltryetoxysilane, as the carrier are magnetite complex with dithyletryaminepentaacetic acid with gadolinium sulfate. | |
Keywords: | magnetite, dithyletryaminepentaacetic acid, gadolinium sulfate, 3-aminopropiltryetoxysilane | |
Edition: | | | | 2014,
,Ukrainian |
097 Magnetic fluid |
Authors: | Gorbyk P.P., Petranovska A.L., Abramov M.V., Turelyk M.P., Pylypchuk Ie.V., Vasilyeva O.A. | |
Summary: | Magnetic fluid includes magnetite, stabilizer and solvent. It further comprises modifiers of organic or inorganic origin, and as a stabilizer are sodium oleate. | |
Keywords: | magnetite, sodium oleate | |
Edition: | Patent of Ukraine № 78448 u 201207629 from 25.03.2013. | | | 2013,
,Ukrainian |
097 Magnetosensitive nanocomposite material |
Authors: | Gorbyk P.P., Petranovska A.L., Pylypchuk Ie.V., Abramov M.V., Vasilyeva O.A. | |
Summary: | Magnetosensitive nanocomposite material containing iron-component - iron and gadolinium borate, which is characterized in that it contains both as iron-component - magnetite, and as gadolinium borate - a mixture of gadolinium ortoborate and gadolinium tetraborate, and additionally as a stabilizer - polyethylene glycol. | |
Keywords: | magnetite, gadolinium borate, polyethylene glycol | |
Edition: | Pat. of Ukraine № 91476 for useful model from 10.07.2014 | | | 2014,
,Ukrainian |
The events in the framework of the project |
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097 4.1. Biocompatible nanostructured materials: interaction with biological systems, safety use, means and methods controlled delivery Purpose:The main goal of the research is to obtain new fundamental knowledge about patterns of physical and chemical processes of chemical synthesis and hierarchical design of nanostructured systems of medical and biological applications, their interaction with external physical fields, radiation, biologically active substances, microbiological objects and development of scientific bases of creation of multifunctional nanocomposites for diagnostics, targeted drug delivery, regognizing of microbiological objects, bind of toxins, destroying of specific cells and remove their decay products from the body Expected results:Release of new product: material Stage 1:Development of technologies for creating of nano-vector drug based on magnetite and anticancer drugs for delivery nanosystems for concentration in the tumor cells; biocompatibility study of the samples in the specified cell lines in vitro. Stage 2:Creation of magnetic-operated nanocomposite based on models forms drugs of cytotoxic action. Synthesis of magnetosensitive nanocomposites based on magnetic fluid comprising the cytostatic drug and "stealth" agent. Preparation of magnetic fluid with cytotoxic properties and low capacity for sorption of plasma proteins. Stage 3:The synthesis and investigation of new types of magnetic fluids based nanocomposites functionalized with cytostatics. Optimization of physico-chemical and technological processes of nanocomposites to create new forms of medicines for oncology. Stage 4:Synthesis and study of properties of new nanostructures based on magnetite and anticancer drug. Creating models medicinal tools of complex action and study of their properties. Stage 5:Creation of scientific bases of synthesis of multifunctional nanomaterials with a hierarchical structure and chemically modified surface functionalized materials development of biological-medical purposes. Development of Nanomaterials for therapy and diagnostics, creation of new dosage forms for oncology.
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