Title: | Methods of directed synthesis and stabilization of nanoscale composites of gold, silver, copper with high antibacterial and anticancer properties are developed |
Type of product: | Improving the effectiveness of diagnosis and treatmentImprove the efficiency of diagnosis and treatment of sick peopleThe obtained results allow to get antimicrobial materials and disinfectants, anticancer drugs, sensors, biomarkers and diagnostic systems. Creating drugs with high antimicrobial activity with extremely low conyent of nanoparticles (NPs) of silver and copper in colloidal and heterogeneous composites. Functionalization of bimetallic NPs Ag/Au with amino acid tryptophan for diagnosis and treatment of malignantly transformed cells. Increased signal in fluorescence and Raman spectra of tryptophan in the presence of gold nanoparticles as a basis for highly sensitive biomarkers creation. |
Description: | There are developed methods of directed synthesis and stabilization of nanoscale composites of gold, silver, copper with controlled morphology, size and optical properties in colloidal solutions and suspensions of silica. Salts of the metals, chemicals or solvents served as starting materials as well as reducing polymer or surfactant as stabilizers. Methods of synthesis are simple, fast and energy efficient and allow to obtain stable nanomaterials with a wide range of structural and functional properties. Highly effective antimicrobial materials and anticancer drugs with low toxicity obtained as aqueous solutions and suspensions of silica.
High antimicrobial activity of drugs against the bacteria Escherichia coli, Staphylococcus aureus, and fungi Candida albicans is saved at the extremely low Cu and Ag NPs concentration in colloidal and heterogeneous composites which is saved more than two years. The method of functionalization of bimetallic Ag/Au NPs with amino acid tryptophan with varying degrees of binding to create products for the diagnosis and treatment of malignantly transformed cells is developed. Evaluation of cytotoxicity of Au (Ag) with conjugated tryptophan in relation to normal and pathogenic cells based on parameters of braking growth and metastasis of carcinoma Lewis and longevity of experimental animals is performed. The enhanced signals of tryptophan in the presence of gold NPs in the fluorescence and Raman scattering spectra are the basis for the creation of highly sensitive biomarkers. The obtained results allow to receive antimicrobial materials and disinfectants, anticancer drugs, sensors, biomarkers and diagnostic systems.
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Technical advantages: | Technical advantages are a significant reduction in energy by chemical or photochemical obtaining materials compared with the methods described in the literature, long-term storage (more than 2 years) their high bactericidal activity against a wide range of microorganisms and fungi, as well as chemical resistance, non-toxic and pronounced antitumor properties .
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The economic benefits: | Low power consumption, cheap raw materials due to extremely low concentrations of precious metals and copper, cheap stabilizers and dispersed silica. |
The impact on the environment. Environment: | Obtained materials have are non- toxic effects for the environment and are biocompatible.
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The stage of completion: | PrototypeThe program is completed, work can be continued to find new composite bactericidal and anti-tumor drugs based on biomolecules, nanoscale metal and oxide materials.
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Implementation: | not implemented |
Intellectual Property Rights: | Patentsnone |
Forms and conditions of transfer of products: | Verification of bactericide and anticancer properties in laboratories of specialized medical institutions in Ukraine as joint research.
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