Publications on the project |
079 Early diagnosis and treatment of prethrombotic state |
Authors: | Lugovskoy Eduard, Gritsenko Pavlo, Koshel Tetyana, Kalchenko Vitaliy, Cherenok Serhiy, Kolesnik Evhen, Komisarenko Sergiy | |
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Edition: | | | | 2010,
XXIth International Fibrinogen Workshop, Rotterdam, The Netherlands. – 2010. – Оral presentation session, Abstr. Р.-12.,English |
079 Calix[4]arene methylenebisphosphonic acids as inhibitors of fibrin polymerization |
Authors: | E.V. Lugovskoi, P.G. Gritsenko, T.A. Koshel, I.O. Koliesnik, S.O. Cherenok, O.I. Kalchenko, V.I. Kalchenko, S.V. Komisarenko. | |
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Edition: | | | | 2011,
FEBS J. – 2011. – 278, P. 1244-1251,English |
079 Synthesis of Calixarene-Methylenebisphosphonic Acids and Their Influence on Fibrin Polymerization |
Authors: | S. O. Cherenok; O. A. Yuschenko; P. G. Gritsenko; E. V. Lugovskoy; T. A. Koshel; V. I. Chernishov; I. O. Koliesnik; O. I. Kalchenko; S. V. Komisarenko; V. I. Kalchenko. | |
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Edition: | | | | 2011,
Phosphorus, Sulfur, and Silicon and the Related Elements, - 2011. - 186: 4, P. 964 — 965.,English |
079 Cleavage of fibrinogen FpA by thrombin induces structural changes within Bbeta121-138 region of molecule |
Authors: | Lugovskoy EV, Urvant LP, Makogonenko EM, Lugovskaya NE, Pydiura NA, Koshel TA, Kolesnikova IN and Komisarenko SV | |
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Edition: | | | | ,
J. of Thrombosis and Haemostasis – 2011 - 9 (Suppl. 2). P. 831.,Ukrainian |
079 Calyx[4]arene methylene bisphosophonic acids as promising effectors of biochemical processes |
Authors: | Komisarenko S. V., Kosterin S.O., Lugovskoy E.V., Kalchenko V.I. | |
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Edition: | | | | 2013,
Biochemistry and biotechnology for modern medicine. K.: Publishing House Moskalenko O.M., – 2013. – С. 293 – 327., |
079 Calix[4]arene C-145, prototype of a multiaction antithrombotic agent: in vivo study |
Authors: | Сhernyshenko V.O., Korolova D.S., Lugovska O.E., Dosenko V.Е., Pashevin D.O., Kalchenko V.I. , Lugovskoy E.V. | |
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Edition: | | | | 2014,
RECOOP 5th TriNet Meeting, 17-19 Oct. 2014: abstracts – Wroclaw, 2014. – P.45-46.,English |
079 5,11,17,23-tertrakis[bis(dihydroxyphosphoryl)methyl]calyx[4]arene or the Na salt thereof as fibrin polymerization inhibitors |
Authors: | Komisarenko S.V., Lugovkoi E. V., Grytsenko P.G., Kalchenko V.I., Koshel (Pozniak) T.A., Cherenok S. O., Yushenko O.A., Kolesnyk E.О. | |
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Edition: | | | | 2011,
International Application No.:PCT/UA2011/000026; Pub. No.: WO/2011/129796 A1 International Filing Date: 11.04.2011. Publication Date: 20.10.2011. ,English |
The events in the framework of the project |
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079 5. Nanobiotechnology Purpose:Calix[4]arene methylene bisphosphonic acid C-192 and its sodium salt C-145 were shown to be efficient inhibitors of fibrin polymerization in vitro (ІС50 was 0,5*10-6 М and 4*10-6 М respectably). After 4 hours after intravenous injection of calix[4]arene C-145 to rabbit the thrombin time and activated partial thromboplastin time were prolonged in 2 and 1,5 times respectively. Other parameters of coagulation and fibrinolysis remained constant. Calix[4]arene C-145 also strongly affected platelet aggregation induced by ADP and provoked thrombocytopenia. So we assumed that effects of calix[4]arene C-145 on haemostasis in vivo consists in selectively inhibition of fibrin polymerization and formation of three-dimensional fibrin network that is the core of thrombus. Expected results:Issue of new types of products: methods, theories Stage 1: Stage 2: Stage 3: Stage 4: Stage 5:
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